• Elevated homocysteine has been considered to be

  2019-09-07

  

  Elevated homocysteine has been considered to be a risk factor for vascular dysfunction, vascular disease, and preeclampsia , . The methionine-homocysteine metabolism is responsible for supplying COMT with the methyl-group donor (-adenosyl methionine; SAM) necessary for 2-ME synthesis, and alteration

• Mass spectrometry has previously been

  2019-09-07

  

  Mass spectrometry has previously been used to examine the presence of Hyp in recombinant collagen, using hydrolysates to identify the individual imino acid, equivalent to an amino molarity formula analysis [33], and also by analysis of mass changes to tryptic peptides [34]. The present study, howev

• In the current study we monitored

  2019-09-07

  

  In the current study, we monitored different groups at risk for CMV reactivation. Similar to the findings from other groups, we observed CMV-reactivations with high-level viremia mostly during the first three months after alloHSCT only in the (D−/R+) and (D+/R+) group [[23], [24]]. Increasing IFN‐γ

• br Study design br Results To

  2019-09-07

  

  Study design Results To explore potential differences in the volume the different swabs absorb, the loss of weight of tubes filled with water after soaking the different swabs under defined conditions was determined. This revealed that the different swabs absorbed between approximately 0.07 an

• Several TERRA binding proteins have

  2019-09-07

  

  Several TERRA-binding proteins have also been discovered, especially telomeric duplex DNA binding proteins TRF1 and TRF2, pointing to a significant role of TERRA in more general chromosome biology [14], [20], [21]. TRF2 is a key component of Shelterin that protect chromosome termini [22]. Telomeres

• In rodents but not humans

  2019-09-07

  

  In rodents but not humans, two splice variants of Chk are identified as Ntk and Ctk, which possess and lack the N-terminal unique domain, respectively. While Ctk is abundantly expressed in the brain, Ntk is selectively restricted to myeloid and lymphoid cells, especially megakaryocytes [31]. This ra

• The highest concentrations from several tens to often

  2019-09-07

  

  The highest concentrations (from several tens to often hundreds or thousands ng/L) are reported in animal farm flush water, and associated runoffs and lagoons in China and in the U.S. Lower concentrations are reported in WWTP influents and effluents. In WWTP influent waters DRO, LNG, NET and PRG hav

• Given the potency enhancing effect of the butyl

  2019-09-07

  

  Given the potency enhancing effect of the 4--butyl group, this substitution was incorporated into the Eastern portion of the molecule for further SAR investigations (). Removal of the phenol group (SR19822) or moving it from the -position to the -position (SR19552) or led to significant loss of acti

• The Wnt catenin signaling pathway is a downstream

  2019-09-07

  

  The Wnt/β-catenin signaling pathway is a downstream target of SOX9 and is involved in a variety of cellular responses, including cell migration, proliferation, and differentiation [14]. Several studies have identified the Wnt/β-catenin signaling pathway as essential for cartilage function, and it is

• br Chain specific ubiquitin probes

  2019-09-07

  

  Chain specific ubiquitin probes The conventional way of assessing linkage specificity is by measuring turnover rates of different diubiquitin molecules as substrates. Although this method has been applied successfully in several studies [7••, 8] it is limited to isolated DUBs, whereas linkage spe

• br Conflicts of interest br Introduction

  2019-09-07

  

  Conflicts of interest Introduction G protein-coupled receptors (GPCRs), form the largest human membrane protein family, with 800 members overall. Many druggable targets for treatment of common diseases involve GPCRs that mediate therapeutic effects of 34% of all marketed drugs (Hauser, Attwood

• Importantly piPolB holds a great promise for developing

  2019-09-07

  

  Importantly, piPolB holds a great promise for developing novel biotechnological applications. For instance, in vitro activities of piPolB, namely, strand displacement and faithful, processive DNA polymerization, can be harnessed for efficient primer-independent whole-genome amplification, whereas th

• br Introduction In addition to

  2019-09-07

  

  Introduction In addition to the canonical double stranded structure, DNA can form various higher order structures such as bulges, and various kinds of mismatches, triplexes, to the G-quadruplex (G4). Over the past decades, accumulating evidence has begun to emerge that these non-canonical structu

• Cyanine 3-dUTP It is believed that emphysema in smokers is m

  2019-09-06

  

  It is believed that emphysema in smokers is mediated by proteases released from inflammatory Cyanine 3-dUTP that cause destruction of the extracellular matrix in alveolar septa [1]. Metalloprotease-12 is mainly released by macrophages and is considered the enzyme responsible for emphysematous lesion

• Although the reasons why viral RNA does not bind

  2019-09-06

  

  Although the reasons why viral RNA does not bind to and activate PKR in WNV-infected cells are not known, some of the known characteristics of flavivirus infections provide possible clues. The viral 4EGI-1 clinical protein forms dimers that associate with ER membranes and viral RNA (Lindenbach et a

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