• All three UbVs were active in

  2020-07-27

  

  All three UbVs were active in vitro and in cells, thereby providing valuable tools for probing the cellular functions of UBE4B, CBL, and XIAP. In addition to regulating p53 stability and function (Wu et al., 2011), ubiquitination by UBE4B also plays a role in endosomal sorting and lysosomal degradat

• Genetic studies from Arabidopsis thaliana often aiming

  2020-07-27

  

  Genetic studies from Arabidopsis thaliana, often aiming at understanding the mode of action of the hormone auxin, have contributed significantly to the identification of NEDD8 pathway components (e.g. [11,21,22]). Here, I review the recent advances in understanding the biochemical processes underlyi

• br Materials and method br Results and

  2020-07-27

  

  Materials and method Results and discussion We carried out DNA ligation using free and immobilized T4 atp citrate lyase in the absence of a magnetic field at 16°C, where the enzyme concentration (final concentration after mixing the solutions for the reaction) in both cases was 0.40μg/mL, and

• DDR and DDR are collagen

  2020-07-27

  

  DDR1 and DDR2 are collagen receptor tyrosine kinases: DDR1 is activated by fibrillar (mainly type I and V) and non-fibrillar (type IV) collagen, and DDR2 is exclusively activated by fibrillar collagen (Alves et al., 1995, Olaso et al., 2002, Valiathan et al., 2012). In normal tissues, DDR1 is expres

• JNK is a member of MAPK family

  2020-07-27

  

  JNK1/2 is a member of MAPK family and studies have shown that JNK1/2 activation promotes neuronal apoptosis (Xia et al., 1995, Le-Niculescu et al., 1999). A previous study has revealed that DAPK physically interacts with protein kinase D (PKD) in response to oxidative stress, and PKD in turn activat

• br Conclusion Four cysteine peptidases from

  2020-07-27

  

  Conclusion Four cysteine peptidases, from B. xylophilus secretome, were further characterised using the previously determined cDNA or genomic DNA sequences and bioinformatics approaches. From these, BxCP3 and BxCP11 were identified as cathepsin L-like proteins and BxCP7 and BxCP8 proteins as cath

• The allele frequency of CYP A was in our

  2020-07-27

  

  The allele frequency of CYP3A5*3 was 79.7% in our study, which agreed with previous studies in the Japanese population [[27], [28], [29]]. Plasma 4β-hydroxycholesterol concentration was significantly different between recipients with and those without CYP3A5*1 allele as we reported previously [23,30

• Since corticotropin releasing factor CRF was isolated and ch

  2020-07-27

  

  Since corticotropin-releasing factor (CRF) was isolated and characterized as the major physiological regulator of the hypothalamus-pituitary-adrenal gland axis and was shown to be responsible for the coordination of the endocrine, autonomic and behavioral responses associated with stress (Vale et al

• br By the results of the rings are

  2020-07-27

  

  By the results of [3], [5] the rings are normal complete intersections, admit only constant homogeneous units and we have unique factorization in the multiplicative monoid of -homogeneous elements of . Moreover, suitably downgrading the rings leads to the Cox rings of the normal rational T-varie

• br Involvement of p and Sp To investigate

  2020-07-27

  

  Involvement of p53 and Sp1 To investigate transcriptional regulation of the COX-2 gene in response to HNE, Kumagai et al. [15] examined whether the HNE-induced COX-2 expression was mechanistically linked to the expression of p53, a transcription factor that regulates the response to a variety of

• br Materials and Methods br Acknowledgements br Introduction

  2020-07-25

  

  Materials and Methods Acknowledgements Introduction Collagen fibrillogenesis, the assembly of collagen fibers, is a critical process in the development, maturation, and repair of mammalian tissue. Alterations in the structure and amount of deposited collagen fibers can greatly alter the int

• Cerulenin In this work we fabricated a kind

  2020-07-25

  

  In this work, we fabricated a kind of multifunctional nanoparticles, based on HAuNS coated by chitosan-stearic Cerulenin copolymer (CSO-SA), which was employed frequently to form micelles for hydrophobic drug delivery in our previous work [21], [22]. The nanoparticles can encapsulate DiR efficientl

• br ILCs anticipate neuronal derived factors

  2020-07-25

  

  ILCs anticipate neuronal-derived factors Recent studies have revealed that ILCs express receptors for neural peptides, thus enabling cross-talk with the peripheral nervous system. ILC3s express RET (Figure 2), which is a receptor for members of the glial cell-derived neurotrophic factor family of

• In this review we present

  2020-07-25

  

  In this review, we present compelling evidence in support of DHODH as an essential enzyme for the survival of cancer cells. DHODH, and its relationship to de novo pyrimidine metabolism, will be discussed along with factors that influence its regulation and expression. We will show evidence of DHODH\

• There have been two reports

  2020-07-25

  

  There have been two reports of tumor shrinkage in response to dasatinib treatment in lung SCC patients harboring the DDR2 kinase domain S768R mutation., In the first case described by Hammerman et al. a combination of erlotinib (an epithelial growth factor receptor inhibitor) and dasatinib was admin

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