• KU-60019: Exploiting ATM Kinase Inhibition for Metabolic ...

  2025-09-25

  Explore how KU-60019, a selective ATM kinase inhibitor, unlocks metabolic synthetic lethality in glioma models by targeting DNA damage response and macropinocytosis. Discover unique applications and advanced therapeutic strategies for cancer research.

• 3X (DYKDDDDK) Peptide: Next-Generation Tag for Quantitati...

  2025-09-24

  Discover how the 3X (DYKDDDDK) Peptide unlocks advanced affinity purification and immunodetection of FLAG fusion proteins, with a special focus on quantitative proteomics and decoding ubiquitin signaling. Explore novel mechanisms, metal-dependent ELISA assay innovation, and future directions in protein research.

• DAPI (hydrochloride): Unraveling DNA Dynamics in Organoid...

  2025-09-23

  Explore the versatile applications of DAPI (hydrochloride) as a DNA-specific fluorescent probe for flow cytometry and organoid research. This article delves into how DAPI enables high-resolution analysis of cell cycle dynamics and lineage diversification in advanced intestinal organoid systems.

• In this study for the first instant we report the

  2025-03-03

  

  In this study, for the first instant we report the characterization, production and in silico structural analysis of BADH1 gene in B. haloduranss SMBPL06 isolated from the salt pan. Moreover, the sequence analysis of betaine aldehyde dehydrogenase from B. haloduranss SMBPL06 displayed several base s

• Some alterations in the integrity

  2025-03-03

  

  Some alterations in the integrity of cell membranes caused by toxic agents can be determined by measuring certain enzymes released by damaged cells [8]. The cholinesterases, for example, catalyze the hydrolysis of R 568 hydrochloride (ACh) in choline and acetic acid. Theses enzymes are divided into

• br Funding br Introduction l Dihydroxyphenylalanine l DOPA

  2025-03-03

  

  Funding Introduction l-3,4-Dihydroxyphenylalanine (l-DOPA) is the gold-standard treatment for the motor symptoms of Parkinson's disease (PD); however, its chronic use induces severe motor complications that eventually limit its long-term efficacy (Bastide et al., 2015). The most disabling side

• Nevertheless though the LO pathway dictates the

  2025-03-03

  

  Nevertheless, though the 5-LO pathway dictates the production of lipid mediators with opposite roles in the immune reactions, like LTs and LXA4 [32], our results seemed to corroborate others that pointed to LTB4 as an outstanding mediator involved in persistent and chronic inflammatory skin diseases

• br Conclusion To conclude it would be

  2025-03-03

  

  Conclusion To conclude, it would be fair to say that the research efforts on FLAP inhibitors for intervening with LT biosynthesis have reached to a considerably advanced state during the last decade as a result of growing interest from both pharmaceutical industry and academia [4], [37], [38]. Du

• Jesus et al discovered a

  2025-03-03

  

  Jesus et al. discovered a new series of azaindole as Aurora inhibitors through various modification of GSK1070916 (47). They synthesized series from modification of the GSK1070916 and evaluated for in-vitro Aurora-B/INCENP and Aurora-A/TPX2 inhibition assays. Modified cy5 dye 48 and 49 showed IC50

• The amino hydroxy methyl isoxazolepropionic acid

  2025-03-01

  

  The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Gastroprokinetic agent antagonist (AMPA) receptor is also enriched in postsynaptic striatal neurons (Bernard et al., 1997, Kondo et al., 2000, Reimers et al., 2011). Its activity is subjected to the regulation by a mechanism involving phosphorylat

• Introduction Cytochrome P CYP aromatase catalyzes the conver

  2025-03-01

  

  Introduction Cytochrome P450 19 (CYP19; aromatase) catalyzes the conversion of androgens to estrogens in a three-reaction sequence, where each step depends on NADPH and O2 [[1], [2], [3]]. The first two steps are accepted to be hydroxylations of the steroid C19 methyl group, whereas the final step

• br Introduction Heart failure HF is a chronically

  2025-03-01

  

  Introduction Heart failure (HF) is a chronically progressive disease and one of the most important causes of morbidity and mortality worldwide despite recent improvements in its treatment [1], [2], [3]. The mortality and morbidity benefits of angiotensin converting enzyme inhibitor (ACEI) are wel

• br Serine glycine and one carbon metabolism Altered serine

  2025-03-01

  

  Serine/glycine and one-carbon metabolism Altered serine metabolism in tumors was noted nearly half a century ago, and elevated flux through the de novo serine synthesis pathway (SSP) is a common phenomenon in cancer PLX4720 [43]. The SSP branches from glycolysis at the point of 3-phosphoglycerat

• In the QFP rs T allele showed

  2025-03-01

  

  In the QFP, rs2269657-T allele showed a significant correlation with reduced plaque density in frontal cortices (Table 2), strengthening the association with amyloid pathology. The same GS1101 region was shown to exhibit a statistically significant reduction of SREBF2 mRNA levels in rs2269657-T car

• OCT also is known as POU F plays an important

  2025-03-01

  

  OCT4 (also is known as POU5F1) plays an important role in embryonic stem cell self-renewal, development and reprogram somatic cell into pluripotent stem cell [[5], [6], [7]]. Recently, many studies also find OCT4 promotes the progression of many tumors. For example, Wnt/β-catenin promotes the expans

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